Writings

A new, emerging paradigm of longevity research focuses on cellular therapies rather than specific metabolic interventions. Cellular epigenetic reprogramming (CER) has been shown to be effective in mouse models of aging damage and injury by regenerating axons in the optic nerve, restoring vision1. CER relies on the introduction of transcription factors Oct3/4, Sox2, and KLF4 into cells using an adeno-associated viral (AAV) vector, enabling them to revert to youthful epigenetic methylation patterns and promoting cellular regeneration. However, since the viral vector can elicit a deleterious immune response2, testing CER in vivo is currently limited to immunologically-isolated tissues and organs. To… Read more: Fixing broken hearts: an innovative approach to life-extension research